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Synthesis, Characterization and Pharmacological Studies of Selenadiazole and Hydrazone Derivatives of 2, 6 Diphenyl 4 piperidone

Author(s): N. Jayalakshmi and S. Nanjundan

Several 2, 6-diphenyl 4–piperidone derivatives were synthesized by Mannich reaction (condensation) of ethyl – methyl ketone, substituted aldehydes and ammonium acetate. The chemical structures were confirmed by means of elemental analysis, IR, and 1H NMR spectral data. The synthesized compounds were evaluated for antibacterial, antifungal, acute toxicity and local anaesthetic activity at various concentrations. Among the compounds examined selenadiazole derivatives of piperidone were found to have good antibacterial and antifungal activity. The hydrazone derivatives exhibited local anaesthetic activity but selenadiazole derivatives were completely devoid of local anaesthetic activity.

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