Synthesis, Characterization and Intramolecular Cyclisation of 5-Substituted Acyclic Nucleosides

Author(s): A. Nura-Lama, M. Bicaj, R. Hoti and A. Musaj

In this paper, synthesis of some new acyclic nucleosides and the intramolecular cyclisation reaction of suitably activated 5-(acetoxymethyl)-1-(2,3-dimethylsulfonyloxypropyl) uracil (4) is described. All compounds were characterised by 1H NMR, 13C NMR and elemental analyses. This intramolecular cyclisation reaction involved nucleophilic attack of the C-2 enoxide ion at the C-2′ rather then at the C-3′ position of the aliphatic chain. The preferred formation of the five-member 2, 2′-anhydro structure was evidenced by the isolation of bicyclical products, 2-methylsulfonyloxymethyl-2,3-dihydro-6- acetoxymethyl-7H-oxazolo [3,2-a]-pyrimidine-7-one (5).

Share this       
izmir escort izmir escort bursa escort antalya escort izmir escort porno porno izle türk porno eskişehir escort bartın escort burdur escort izmir escort bursa escort porno indir izle escort izmir