Synthesis, Characterization and Antimicrobial Study of New S-Maltosylated 1,2,4-Thiadiazolines

Author(s): U. W. Karhe and S. P. Deshmukh

A series of 2-aryl-5-phenylimino-3-S-hepta-O-benzoyl maltosyl-1, 2, 4-thiadiazolines 2 have been synthesized by the oxidative cyclization of S-hepta-O-benzoyl maltosyl-1-aryl-5-phenyl-2, 4- isodithiobiurets 1 by using bromine in chloroform as oxidizing agents. The identities of these new compounds have been established on the basis of chemical transformations and IR, 1H NMR and Mass spectral studies. The antimicrobial study of these S-maltosides have been evaluated by using Escherichia coli, Staphylococcus aureus, Proteus vulgaris, Pseudomonas aeruginosa, Candida albicance and Aspergillus niger. The study reveals that most of the compounds show satisfactory antimicrobial activities.

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