44 7460 854 031

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis, Characterization and Anti-microbial Screening of Novel Heterocyclic Systems containing Bridgehead Nitrogen Atom

Author(s): G. Om Prakash, Y. Anjaneyulu, N. Siva Subramanian, M. Ramadevi and G. Vijayala

The facile synthesis of 3-substituted-2-phenyl-benzimidazo[2, 1b] pyrazolo [3,4 d] [1, 3] thiazole (4a-j) has been achieved by the reaction of 2-mercapto benzimidazole with chloroacetic acid. It affords benzimidazol-2-thio acetic acid (1), which on cyclization with a mixture of acetic anhydride and pyridine furnishes thiazolo (3, 2-a) benzimidazol-3 (2H)-one (2), (2) on condensation with different aryl aldehydes furnishes arylidine thiazolidinone (3a-j) followed by treatment with phenyl hydrazine in the presence of sodium acetate affords (4a-j). All the synthesized compounds have been supported by spectral analysis. The antimicrobial activity of synthesized compounds has also been evaluated.


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More