Synthesis, Characterization and Anti-Microbial Activity of Novel Substituted Benzoxazole Derivatives

Author(s): G. Balaswamy, K. Srinivas, P. Pradeep and M. Sarangapani

In view of the fact that a large number of derivatives of benzoxazole have been found to exhibit a wide variety of pharmacological activities. In the current research work, the title compounds were synthesized from 2-substituted benzoxazole-5-carbohydrazide (1) on treatment with equimolar quantities of anhydrides afforded 1-[(2-substituted-1,3-benzoxazol-5-yl)carbonyl]-1,2-dihydropyridazine-3,6-dione (2), of 1-[(2-substituted-1,3-benzoxazol-5-yl) carbonyl] tetrahydropyridazine-3,6-dione (3) and 2-[(1,3- benzoxazol-5-yl)carbonyl]-2,3-dihydrophthalazine-1,4-dione (4). The identification and characterization of all the synthesized compounds were confirmed by elemental analysis, melting point, Thin layer chromatography, FT-IR, 1H NMR and mass spectral data. All the compounds were screened for antimicrobial activity. In view of interesting biological activities and pharmacological importance associated with benzoxazole derivatives hence, the some of the derivatives of benzoxazole containing heterocyclic ring have been prepared and their bio-potential have been evaluated.

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