44 7460 854 031

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Synthesis, Antimicrobial and Cytotoxic Activities of Some Bio-isosteres of 1, 3, 4-Oxadiazoles

Author(s): Upadhyay PK and Mishra P

In the present study, 5-(4-substituted phenyl)-1, 2, 4-triazole-3-thiol (5a-e) were synthesized from 5-(4-substituted phenyl)-1, 3, 4-oxadiazole-2-thiol (4a-e) and their structures were confirmed by IR, NMR, Mass spectral and elemental analysis. These synthesized compounds were screened for the antimicrobial and cytotoxic activities. The results indicated that, compound 5(a) and 5(b) showed the highest antibacterial activity. Compound 5(d) and 5(e) were observed to be the most potent antifungal agents. The structure activity relationship discovered that the presence of electron withdrawing and electron donating substituents at para position of phenyl ring of synthesized compounds enhance the antibacterial and antifungal activities, respectively. Further, the results of cytotoxicity studies on breast cancer cell line (MCF-7) suggested that active antimicrobial agents 5(a), 5(b), 5(c), 5(d) and 5(e) are accompanied with low cytotoxicity. The biological profiles of these 1, 2, 4-triazoles would be a fruitful matrix for further development of safe and efficacious compounds.

Share this       
Google Scholar citation report
Citations : 4955

International Journal of Chemical Sciences received 4955 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research

Read More

Global Tech Summit
Yeni acilan ve cok kazancli olan Matadorbet guncel giris yapip uyelik gerceklestirebilirsiniz.