Synthesis, Antiinflammatory and Antibacterial Activities of some Substituted Isatin and Isatin fused with 3-Substituted 4-Amino-5-mercapto-1, 2, 4-triazoles

Author(s): Subhas Sahoo, C. B. Mahendrakumar and C. Mallikarjuna Setty

The synthesis of 1, 2, 4-triazoles have attracted popularity and interest in recent years. The literature studies have shown that more work is not carried out on the fused triazole and isatin derivatives. In this context, we explored the modification in the structures of some synthesized isatin derivatives and prepared some substituted triazole fused with isatin. The present study focuses on new antiinflammatory and antimicrobial properties of 1, 2, 4-triazoles. The aryloxy acetic acid and hydrazine hydrate is useful for the preparation of substituted aryloxy acid hydrazides and extend the preparation of various isatin semicarbazones by reacting with prepared basic isatin. The structures of compounds were confirmed on the basis of their elemental analysis, IR, 1H NMR and Mass spectral analysis, were screened for antiinflammatory and antibacterial activities. Among all the synthesized compounds, SI-5 and 1C have shown potent antibacterial activity where as other compounds exhibited moderate antibacterial activity. The antiinflammatory and antimicrobial activities of title compounds were comparable to that of standard drug ibuprofen and norfloxacin, respectively. The pharmacological studies demonstrate that compounds SI-5, IB, IC and ID can be chosen as lead for additional modification.

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