All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Synthesis, Anti-HIV Activity and Cytotoxicity Studies of Novel 2-Phenyl, 3-substituted quinazolin-4(3H)-one Derivatives

Author(s): P. Selvam, P. Babu, Padam Raj Rathore and Myriam Witvrouw

A series of novel 2, 3-disubstituted quinazolin-4(3H)-one derivatives have been synthesized by condensation of 2-substituted benzo[1, 3]oxazine-4-ones and primary amines. Their chemical structures were assigned by means of spectral analysis (FT-IR, 1H-NMR, MS). Synthesized compounds were screened for in vitro antiviral activity against HIV-1(IIIB) in MT-4 cells. All the compounds displayed cytostatic properties in T lymphocytes cells and compounds QPABA and MSQN exhibited 19 and 16 percent maximum protection, respectively against HIV-1 at sub toxic concentration.

Share this       

Recommended Conferences