Abstract

Synthesis and Evaluation of Antifungal Activity of Novel Indole Derivatives

Author(s): S. D. Kulkarni, A. N. Tankar, B. G. Ram, D. B. Ghongade, B. G. Chandak and R. N. Tiwari

Novel Mannich bases of indole were synthesized by using a series of secondary amines and formaldehyde in presence of ethanol with magnetic stirring for 4-6 hours in cold condition. The structures of these compounds were established on the basis of spectral data. The final compounds were screened for antifungal activity against Candida albicans using cup- plate method. Ketoconazole was used as standard drug.