Abstract

Synthesis and Evaluation of Amide Prodrugs of Mefenamic Acid

Author(s): V. S. Tegeli and H. N. More

A series of amide prodrugs of mefenamic acid (a known non-steroidal anti-inflammatory drug) have been synthesized with an aim to obtain new compounds with potential analgesic and anti-inflammatory activity. The structures of all synthesized compounds were confirmed by means of infrared, proton magnetic resonance and mass spectroscopy. All compounds were evaluated for their anti-inflammatory activities by carrageenan-induced rat paw edema test. Most of the synthesized compounds induced significant reduction in the writhing response when compared to control. The anti-inflammatory activity of these compounds were evaluated and showed significant anti-inflammatory activity in comparison to control but their effect was weaker than mefenamic acid.


Share this       
izmir escort izmir escort bursa escort antalya escort izmir escort porno porno izle türk porno eskişehir escort bartın escort burdur escort izmir escort bursa escort porno indir izle istanbul escort istanbul escort bayan escort izmir