Synthesis and Characterization of Biologically Active Metal Complexes of Coumarin Derivatives

Author(s): K. B. Vyas, K. S. Nimavat, G. R. Jani and M. V. Hathi

This paper reports the isolation of ML2 complexes, where, M = 3d5 to 3d9 elements and ligand L is 3-[{3-(3'-chloro)}-prop-2-enoyl] -4-hydroxy-6-methyl-2H-chromen-2-one. The metal complexes are synthesized and characterized by elemental analysis, IR spectra and conductivity measurements. All metal complexes are highly stable and non-hygroscopic. In vitro anti microbial activity of all synthesized compounds and standard drugs have been evaluated against four strains of bacterial culture and one fungus, which includes two gram +ve bacterial culture and two gram -ve bacterial culture, which show net enhancement in activity on co-ordination of metals with ligand but moderate activity as compare to standard drugs.

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