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Synthesis and Biological Evaluation of 4-Aryl - 3-Chloro 1 Nicotinamido 2 Azetidinones as Potential Anticonvulsant and Antimycobacterial Agents

Author(s): N. Ramalakshmi, R. Vijayakumar, K. Ilango, S. Arunkumar and A. Puratchikody

In the present study novel series of 4 - aryl – 3 - chloro – 1 – nicotinamido – 2 -azetidinones were synthesized and characterized by means of IR, 1H- NMR, Mass spectral analysis. The compounds were screened for anticonvulsant and antimycobacterial activities. Antimycobacterial activity was screened using standard Strain H37RV and two Human Strains (Human strain-I and Human strain-II) isolated from patients suffering from pulmonary tuberculosis. The minimum inhibitory concentration (MIC) of C3, C5 , C6, C9 , against standard Strain H37RV was found to be 50-100 μg/mL, for Human strain-I and Human strain-II, the MIC was found to be 100-200 μg/mL. Anticonvulsant activity was tested in Wistar rats by maximal electro shock (MES) method. Compounds C1, C2 , C3, C4 , C5, C6 , C8, C13 and C14, showed significant anticonvulsant activity and compounds C9, C10 , C11 and C12 showed moderate activity.

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  • Cosmos IF
  • Geneva Foundation for Medical Education and Research

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