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Abstract

Synthesis and Biological Evaluation of 3-Aryloxy Methyl 4-[- 2(Benzimidazolyl Thio) Acetamide]-5-Mercapto-1,2,4-Triazoles.

Author(s): B. Shivkumar, Shobharam Sahu, T. Y. Pasha, R. H. Udupi, A. R. Bhat, R. Nagendra Rao and A. Veeranagoud

Aryloxy potassium dithiocarbazintates (IV) were prepared by reaction of aryloxy acid hydrazides (III) with alcoholic KOH and CS2 , which when cyclised with 2-(benzimidazolyl thio) methyl acetic acid hydrazide (V) gave 3-aryloxymethyl-4-[2-(benzimidazolyl thio) acetamido]-5-mercapto- 1,2,4-triazoles (VI a-h).The structures of the new compounds were characterized on the basis of analytical and spectral data. Antimicrobial activities of synthesized compounds was evaluated and some of the compounds exhibited promising activity.


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