All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis and Antiviral Activity of Some Novel 6-Bromo/6, 8-dibromo, N-benzoyl-4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-Benzenesulphonamide

Author(s): P. Selvam, C. Pannecouque and E. De Clercq

A series of novel 2, 3-disubstituted quinazolin-4(3H)-one derivatives have been synthesized by condensation of 2-substituted 1, 3-benzoxazin-4-ones and sulphabenzamide. Their chemical structures were assigned by means of spectral analysis (FT-IR, 1H-NMR, MS). Synthesized compounds were screened for antiviral activity against HIV 1 and 2 in MT-4 cells. Compound SPB exhibited 47 percent maximum protection against replication of HIV-1 in acutely infected MT-4 cells.


Share this       

Recommended Conferences

Flyer