Synthesis and Antitubercular Activity of 6-Nitro-2-[4-Formyl-3-(substituted Phenyl) pyrazol-1-yl] Benzothiazoles

Author(s): A. A. Chowki, C. S. Magdum, P. L. Ladda and S. K. Mohite

Various 6-nitro-2-[4-formyl-3-(substituted phenyl) pyrazol-1-yl] benzothiazoles were synthesized and screened for antitubercular activity against H37Rv strain of Mycobacterium tuberculosis by proportion method on Lowenstein Jensen (LJ) media. Synthesis of 6-nitro-2-[4-formyl-3-(substituted phenyl) pyrazol-1-yl] benzothiazoles reported in this study provides a novel example of Vilsmeier Haack reagent mediated heterocyclic synthesis. 6-Nitro-2-[4-formyl-3-(substituted phenyl) pyrazol-1-yl] benzothiazoles exhibit a range of activities in the antitubercular screens. Compounds IVh and IVj emerged as the most promising active compounds comparable to that of standards

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