All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Synthesis and Anticandidosic Activities of Imidazo[1,2-a]pyridinehydrazone Derivatives

Author(s): Souleymane Coulibaly

The synthesis and antifungal activity study of new hydrazide hydrazones derivatives (5a-r) containing the imidazo[1,2-a]pyridine backbone are presented in this paper. They were obtained by condensation reaction between 2-hydrazino-3-nitroimidazo[1,2-a]pyridine 3 and various aromatic aldehydes (4a-r) in the presence of acetic acid under reflux of methanol. Synthesized compounds were characterized by 1H, 13C Nuclear Magnetic Resonance (NMR), and High-Resolution Mass Spectrometry (HRMS) analyses. Among these compounds, twelve (12) were evaluated for their potential antifungal activity on Candida albicans n°396 from the CeDReS collection. The results demonstrate that antifungal activity varies according to the substituent present on the phenyl ring of each derivative. The weakly electron-donating or electron-withdrawing compounds seem to be the most active. Thus, methylated (5b) and brominated (5e) derivatives were the most efficient with respectively minimum inhibition concentrations (MICs) of 4.06 and 8.61 µmol/L.

Share this       
Google Scholar citation report
Citations : 256

ChemXpress received 256 citations as per Google Scholar report

Indexed In

  • CASS
  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Cosmos IF
  • Directory of Research Journal Indexing (DRJI)
  • Secret Search Engine Labs
  • Scholar Article Impact Factor (SAJI))

View More