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Synthesis and Anticancer Activity of Some Novel 2-Substituted Benzothiazole

Author(s): V. P. Devmurari, Pandey Shivan, M. B. Goyani, R. R. Nandanwar, N. P. Jivani and P. Perumal

The series of seven substituted 2-phenyl-benzothiazole and substituted 1, 3-benzothiazole-2 -yl-4- carbothiaote derivatives were synthesized. Substituted 2 -phenyl-benzothiazole were synthesised by condensing substituted benzoic acid with 2-amino thiophenol in the presence of phosphoric acid and 3- benzothiazole-2-yl-4-substituted carbothiaote derivatives were prepared by condensing 2-mercaptobenzothiazole with substituted acid chloride. Structures of all the compounds were characterized by spectral and elemental analysis. All the synthesised novel compounds were screened for anticancer activity. It was also found that compounds 1, 2, 6 and 7 showed very good anticancer activity whereas all the other compounds showed mild to moderate anticancer activity as compared to standard drug.

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