Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerSynthesis and Antibacterial Effect of 2-(Benzylthio) Methyl-1h-Benzimidazole Derivatives on Two Bacteria of Medical Interest| Abstract

Abstract

Synthesis and Antibacterial Effect of 2-(Benzylthio) Methyl-1h-Benzimidazole Derivatives on Two Bacteria of Medical Interest

Author(s): Souleymane Coulibaly

This work involved the synthesis of ten (10) novel 2-benzylthiomethyl-1H-benzimidazole derivatives (5a-d) and evaluation of their antibacterial activities. These new compounds were synthesized by reacting the isothiouronium-1H-benzimidazole salts (3a and 3b) with the benzyl halides (4) to ethanol reflux in the presence of a sodium hydroxyde solution. The obtained compounds were characterized by nuclear magnetic resonance 1H, 13C NMR and High-Resolution Mass Spectrometry (HRMS). These compounds were evaluated for antibacterial activity on two bacterial strains, Escherichia coli and Staphylococcus aureus. The results showed that on S. aureus, six compounds (5b, 5d, 5e, 5f, 5g and 5j) were significantly potent with antibacterial activity MIC values ranging from 140 to 320 µg/mL. On the bacterial strain E. coli, five compounds (5b, 5e, 5g, 5h and 5j) showed a significant antibacterial effect with MIC ranging from 140 to 400 µg/mL.


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Citations : 748

Acta Chimica and Pharmaceutica Indica received 748 citations as per Google Scholar report

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