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Synthesis and Antibacterial Activity of Phenothiazine-3-Sulfonate Derivatives

Author(s): M. Vasudha, G. Mohan Rao, A. Anna Reddy and Vijay Kumar Baru

Phenothiazine derivatives are biologically active and pa vital role in medicinal chemistry. The present report explains a simple and efficient synthesis of title compounds. The compounds are also screened for their biological activity and shown good results. Potassium 1-amino-10,10a-dihydro-4aH-phenothiazine- 3-sulfonate (1) reacts with Benzaldehyde to form Potassium-1-(benzylideneamino)-10,10a-dihydro-4aHphenothiazine- 3-sulfonate (2), which undergoes N-alkylation to give potassium-1-(benzylideneamino)- 10,10a-dihydro-10-((oxiran-2-yl)methyl)-4aH-phenothiazine-3-sulfonate (3). Compound 3 reacts with different amines to give Potassium-1-(benzylideneamino)-10, 10a-dihydro-10-(2-hydroxy-2-(pyrrolidin-1- yl)ethyl)-4aH-phenothiazine-3-sulfonate (4a-e). All the newly synthesized quinoxaline-benzohydrazide derivatives have been characterized by 1H NMR, IR and mass spectroscopic analysis. The synthesized compounds have been screened for antibacterial activity. Most of the compounds show significant antibacterial activity.

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Citations : 4955

International Journal of Chemical Sciences received 4955 citations as per Google Scholar report

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  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research

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