Synthesis and Antibacterial Activity of Mannich Bases of 3, 4-Dihydro-8-Methoxy-2H-1, 2, 4-Triazino[3, 4-b] Benzothiazole-3, 4-Dione

Author(s): S. P. Vartale, V. N. Bhosale, S. V. Khansole, P. A. Kulkarni and J. S. Jadhav

2-Hydrazino-6-methoxy benzothiazole (1) in methanol on reaction with diethyl oxalate in the presence of pyridine afforded 3, 4-dihydro-8-methoxy-2H-as-triazino[3, 4-b]-benzothiazole-3, 4-dione (2). The latter on further reaction with formaldehyde and different heteryl amines such as morpholine, pyrrolidine and pipyridine afforded Mannich bases (3,5). The newly synthesized compounds were subjected to evaluation for antibacterial activity.

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