Synthesis and Antibacterial Activity of 6,7-Bis[3-(4-Substituted Phenyl)-4- Oxo-Thiazolidin-2-Ylidene Amino]Quinoxaline-2,3 (1H,4H)-Diones

Author(s): P. Y. Pawar and S. B. Bhise

6,7-Diaminoquinoxaline-2,3(1H,4H)-dione (1) on treatment with substituted aromatic isothiocyanate yielded 6,7-bis[3’-aryl thiocarbamido]-quinoxaline-2,3(1H,4H)-diones (2a-e), which on cyclisation with monochloroacetic acid in presence of anhydrous sodium acetate and glacial acetic acid afforded 6,7-bis[3-(4-substitutedphenyl)-4-oxothiazolidin-2-ylideneamino]quinoxaline-2,3 (1H, 4H)- diones (3a-e). The constitution of the synthesized compounds is supported by IR, 1H NMR, Mass and elemental analysis. The compounds were subjected to preliminary in vitro evaluation for antibacterial activity against various Gram-positive bacterial strains Staphyllococus aureus, Bacillus cereus and Gram-negative strain Pseudomonas aeuroginosa

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