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Study of the Binding Ability of Molecular Imprinted Solid Phase Extraction for Glibenclamide by Optimizing Template : Monomer : Crosslinker Ratio

Author(s): Aliya Nur Hasanah, Tridessy Nanda Sari, Natalia Wijaya, Rahmana Emran Kartasasmita and Slamet Ibrahim

Five molecularly imprinted polymer for glibenclamide was prepared by using glibenclamide as the template, acrylamide as the functional monomer and ethyleneglycoldimethacrylate as a cross linker in different ratios. Binding ability analysis showed that acetonitrile pH 4 is the best solvent for rebinding of the analyte. The imprinting factor (IF) was calculated by comparing the retention of glibenclamide on the imprinted polymer with a comparable non-imprinted polymer. The template : monomer : crosslinker ratio of 1:6:70 resulted in an IF of 6.85. This MIP has the potential for use in SPE for purification and concentration of glibenclamide and with further optimization.

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