Study of dyslipidemia in patients of type 2 diabetes mellitus

Author(s): Anju Sharma, Neha, Shailja, Sahiba Kukreja, Jaskiran

Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. The characteristic features of diabetic dyslipidemia are a high plasma triglyceride concentration, lowHDL cholesterol concentration and increased concentration of small dense LDL-cholesterol particles. The lipid changes associated with diabetes mellitus are attributed to increased free fatty acid flux secondary to insulin resistance. This was a case control study. The sub­jects who were included in the study were divided into two groups. Group A included 50 normal healthy individuals who were in the age group of 40-65 years, who were of either sex and with no family history of Diabetes mellitus. Group B includ­ed 50 newly diagnosed patients of Type 2 Diabetes Mellitus, who were in the age group of 40-65 years, who were of either sex, from the same population. Fasting blood samples were drawn and they were investigated for the serum insulin, serum uric acid, fasting blood sugar, HbA1C levels and lipid profile. The values were comparedwith those of normal healthy subjects.All the parameters, FBS,HbA1C and serumlipid profile were found to be increased in the patients of Type 2 DiabetesMellitus as compared to their levels in the con­trols (p<0.001). In the present study, it was concluded that Serum total cholesterol, serum triglyceride, LDL andVLDLwere significantly raised in diabetics while serumHDL- C levels were significantly decreased when compared to healthy individual.

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