Studies on Synthesis of Some Biologically Important N-Glycosylated-3-Amidino Carbamides as Antibacterial and Antifungal Agents

Author(s): Monika R Thakur and Shirish P. Deshmukh

Condensation of several acetyl/benzoyl glycosyl isocyanates and guanidine resulting in the formation of N-glycosylated-3-amidno carbamides has been studied. The required acetyl/benzoyl glycosyl bromides were prepared by the processes of acetylation, benzoylation followed by bromination. This was converted in to acetyl/benzoyl glycosyl isocyanates by the reaction respective glycosyl bromides with lead cyanate. The identities of these newly synthesized compounds have been established on the basis of usual chemical transformations, elemental analysis and IR, 1H NMR and Mass spectral studies. The compounds have been screened for their antibacterial activity against E.coli, S. aureus, P. vulgaris, S. typhi and K. pneumoniae and for antifungal activity against P. species and A. niger. The study reveals that most of the compounds show promising activities.

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