Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerStudies on Solid Dispersed Etoricoxib with Newer Carriers| Abstract

44 7460 854 031

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Studies on Solid Dispersed Etoricoxib with Newer Carriers

Author(s): A. Prameels Rani, R. Santosh Kumar and N. Sarat Babu

Etoricoxib (ETO) is a non-steroidal anti-inflammatory drug, which is widely used in symptomatic relief of osteoarthritis and rheumatoid arthritis. One of the major problems of this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. Therefore, solid dispersion of ETO with newer carriers i. e., croscarmellose sodium (CCS) and crospovidone (CP) were prepared using CCS and CP in three ratios (1 : 1, 1 : 2 and 1 : 3) employing physical mixing method and solvent evaporation method. The drug release profile for pure drug as such and its solid dispersions was determined. ETO was released at much higher rate from its solid dispersions as compared to that of pure drug. Faster dissolution rate was observed in drug : CCS (1 : 3 ) prepared by co-evaporation method. The increase in dissolution rate of drug may be due to increase of wettability, hydrophilic nature of carrier and also due to reduction in drug crystallinity, which is supported by DSC thermograms.


Share this       
Google Scholar citation report
Citations : 4955

International Journal of Chemical Sciences received 4955 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research

Read More

Flyer
Yeni acilan ve cok kazancli olan Matadorbet guncel giris yapip uyelik gerceklestirebilirsiniz.