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Studies on Diluents for Formulation of Tablets

Author(s): V. P. Pandey, K. Venkateswara Reddy and R. Amarnath

Lactose monohydrate, dibasic calcium phosphate (DCP) and microcrystalline cellulose phosphate (MCCP) were studied as diluents in the same quantity for manufacture of chloroquine phosphate tablet using polyvinyl pyrrolidone K-30 (PVP K-30) as binding agent and sodium starch glycolate (S.S.G.) as disintegrating agent. In the present study, it was found that lactose monohydrate was suitable diluent for chloroquine phosphate tablets considering hardness and disintegration time. There were not much variations in other parameters like Hausner’s ratio, compressibility index, angle of repose and friability for all the three diluents.

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