Spectrophotometric Method for the Validation of Indinavir in Pharmaceutical Dosage Forms

Author(s): K. Parameshwara Rao

The spectrophotometric methods for the determination of Indinavir in pure and dosage forms have been described in this paper. The present methods involve the determination of Indinavir in pharmaceutical dosage at the given optimum conditions. The stock solution of Indinavir was prepared by dissolving 100 mg of the pure Indinavir drug in 10.0 mL of methanol and made up to 100 mL with distilled water to get a clear solution. Appropriate volumes of this stock solution were diluted step wise to get the working standard solutions of concentrations 200 μg/mL for Method-M9. The values obtained by the proposed and reference method for formulations were compared statistically with F and t tests and found not to be different significantly. A simple and a cheap UV spectrophotometric method was developed and validated for the quantitative estimation of Indinavir sulphate in capsules as per ICH guidelines and hence it can be used for the routine analysis in various pharmaceutical industries.

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