Spectrophotometric Estimation of Cefditoren Pivoxil in Pharmaceutical Oral Solid Dosage Form

Author(s): V. Niraimathi, Ajithadas Aruna, A. Jerad Suresh and V. Prema

Two simple, sensitive, economical, accurate and precise spectrophotometric methods have been developed for the estimation of cefditoren pivoxil in pharmaceutical oral solid dosage form. Method A involves the determination of cefditoren pivoxil by diazotisation reaction. It is based on the reaction of cefditoren pivoxil with hydrochloric acid and sodium nitrite to form reddish brown colored chromogen, exhibiting maximum absorption at 450 nm. Method B is based on reaction of cefditoren pivoxil with ferric chloride and 1, 10-phenanthroline to form blood red coloured chromogen, exhibiting absorption maximum at 510 nm. The Beer’s concentration was found to be between 50-500 µg/mL for Method A and 5-50 µg/mL for Method B. The methods have been statistically evaluated and were found to be precise and accurate. The proposed methods are economical and sensitive for the estimation of cefditoren pivoxil in bulk drug and formulations.

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