Spectrophotometric Determination of Lamotrigine in Pharmaceutical Dosage Forms

Author(s): M. Purushotham Reddy, P. Ravindra Reddy and N. Rami Reddy

A simple and sensitive spectrophotometric method for the determination of lamotrigine in bulk drug and pharmaceutical dosage forms has been developed. The developed spectrophotometric procedure was based on the reaction of lamotrigine with vanillin under acidic conditions to form yellow coloured chromogen with absorption maxima at 390 nm against reagent blank. Beer’s law was obeyed in the concentration range of 40-100 μg/mL of drug. The method was successfully applied to the determination of lamotrigine in tablets.

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