Abstract

Spectrophotometric Determination of Amisulpride

Author(s): S. Humairaa, A. K. Deya, S. Sanaullahb and S. A. Raju

Three simple and sensitive spectrophotometric methods (A, B and C) have been developed for the quantitative estimation of amisulpride in bulk drug and pharmaceutical dosage forms. Method A is based on the diazotisation of amisulpride with nitrous acid followed by its coupling in situ with N-(1- naphthyl) ethylenediamine dihydrochloride to form pink coloured chromogen exhibiting absorption maximum at 523.5 nm and Beer’s law is obeyed in the concentration range of 2-10 μg/mL. Method B is also based on the diazotisation of drug with nitrous acid followed by its coupling insitu with -naphthol to form orange coloured chromogen exhibiting absorption maximum at 482.5 nm and Beer’s law is obeyed in the concentration range of 2-10 μg/mL. Method C is based on the reaction of amisulpride with Folin-Ciocalteau (FC) reagent in alkaline condition to form stable blue coloured chromogen with absorption maximum at 736 nm and Beer’s law is obeyed in the concentration range of 10-50 μg/mL. The results are compared with those obtained using UV spectrophotometric method in 0.1N HCl at 226.5 nm


Share this       
izmir escort izmir escort bursa escort antalya escort izmir escort porno porno izle türk porno eskişehir escort bartın escort burdur escort izmir escort bursa escort porno indir izle istanbul escort istanbul escort bayan escort izmir