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Spectrophotometric Determination of Almotriptan in Pharmaceutical Dosage Forms

Author(s): D. Dharani Kumari, M. Manjula Gayatri and N. Lalitha Kumari

A simple and sensitive spectrophotometric method has been developed for the determination of almotriptan malate in pharmaceutical preparations. In this method 2, 3-dichloro-5,6-dicyano-pbenzoquinone (DDQ) was utilized for determination of almotriptan malate forming charge transfer complex with maximum absorbance at λmax 390 nm. Optimization of the reaction conditions has been investigated. Obediance to Beer's law permitted the assay of almotriptan malate in their dosage form. The proposed method is simple, rapid accurate, precise, reproducible, and economic and can be used for routine quantitative analysis of almotriptan malate in pure and tablet dosage form.

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