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Simultaneous Estimation of Mefenamic Acid and Paracetamol in Suspension Form by using UPLC

Author(s): D. Mahaboob Basha and K. Ananda Reddy

A simple, fast, precise, specific, accurate reversed phase ultra performance liquid chromatographic (UPLC) method was developed and validated for the simultaneous determination of Mefenamic acid (MA) and paracetamol (PC) in suspension. The column used was acquity, BEH C18 50 mm* 2.1 mm, 1.7 µm and a mobile phase composed of Acetonitrile : 0.1 % Formic Acid in water (95:05), The flow time was set at 0.6 mL/min. Analysis was performed using PDA detector, The column temperature was 35o C. The retention times of MA and PC were found to be 2.86 min and 1.03 min, respectively. Linearity was established for MA and PC in the range of 10-60 µg/mL and 10-60 µg/mL, respectively. Repeatability and intermediate precision were acceptable (RSD < 2%). The percentage recoveries of MA and PC were found to be in the range of 99.42% to 100.04% and 100.05% to 100.80%, respectively. The proposed method was validated and successfully used for estimation of Mefenamic acid and paracetamol in the pharmaceutical dosage form.

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