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Simultaneous Determination of Simvastatin and Ezetimibe by Liquid Chromatography

Author(s): B. Neelima, P. Ravi Kumar, V. Hima Bindu and Y. Rajendra Prasad

A simple, precise and rapid RP-HPLC method was developed for the simultaneous determination of simvastatin and ezetimibe in combined pharmaceutical dosage forms. The method was carried out on a Shim-pack, RP-C18 column using a mixture of acetonitrile : 0.1% v/v orthophosphoric acid and detection was done at 239 nm using external standard method as quantitation. The linearity range of simvastatin and ezetimibe were 0.1 to 25 =g/mL. The intra-day and inter-day precision were in the range of 0.16-0.20 and 0.25-0.46 for simvastatin, 0.86-1.43 and 0.35-0.93 for ezetimibe.

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