Simple U.V. Spectrophotometric Methods for the Estimation of Ofloxacin in Pharmaceutical Formulations

Author(s): C. Sowmya, Y. Padmanabha Reddy, J. Ravindra Reddy, M. Siva Maruthi, G. T. Roopesh and M. Santhosh Raja

The present work was aimed to develop two simple and sensitive UV spectrophotometric methods for the estimation of ofloxacin in bulk and in dosage forms. Ofloxacin is one of the most promising newer members of the fluoroquinolone family of antibacterials. Ofloxacin shows the obsorption maxima at 284.0 nm in pH 6.8 phosphate buffer and 286.0 nm in pH 7.2 phosphate buffer with an apparent molar absorptivities of 4.1558 x 104 and 3.0717 x 104 , respectively and obeyed the Beer’s law in the concentration range of 1-6 µg/mL and 1-10 µg/mL. Both the proposed methods were applied for the estimation of different ofloxacin tablets with mean percent accuracies of 99.2 ± 3.1 and 104.6 ± 1.89, respectively with method A and 99.01 ± 0.45 and 99.24 ± 0.34, respectively with method B.

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