Simple Extractive Spectrophotometric Determination of Rupatadine as Rupatadine Fumarate from Pharmaceutical Formulation

Author(s): R. V. Rele, P. D. Desai and S. A. Sawant

Simple, sensitive and accurate extractive spectroph otometric methods have been developed for the estimation of rupatadine as rupatadine fumarate from pharmaceutical dosage form. The methods were based on the formation of coloured complexes by the drug with reagents like bromothymol blue, bromophenol blue and methyl orange in acidic medium . The ion associated complexes were formed and quantitatively extracted under the experimental con dition in chloroform. The absorbance values were measured at 416, 418 and 422 nm, respectively. The proposed methods were validated statistically. Recoveries of methods were carried out by standard addition methods. The linearity was found to be 1.0 - 12.0  g/mL, 1.0-16.0  g/mL and 1.0-28.0  g/mL for methods I, II and III, respectively. The l ow values of standard deviation and percentage RSD indicate high precision of methods. Hence, these methods are useful for routine estimation of rupatadine as rupa tadine fumarate in tablets.

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