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Selection of Size Reduction Technique in API (Pharmaceutical) Industry

Author(s): Aniruddha Shinde

The size reduction generally induced amorphization and/or structural disordering of the drug crystal (mechanochemical activation). The size reduction enhances drug dissolution and solubility include alterations in the size, specific surface area and shape of the drug particles. Size reduction technology such as milling now enable the production of drug micro- and nano-particles on a commercial
scale with relative ease. This review will provide a background on milling followed by the introduction of common milling techniques employed for the size reduction of drugs. Salient information contained in the cited examples are further extracted and summarized for ease of reference by researchers keen on employing these techniques for drug solubility and ease in formulation preparation.

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