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Quantitative Determination of Bisoprolol Fumarate in Bulk and Pharmaceutical Dosage Forms by Spectrophotometry

Author(s): G. Tuljarani, D. Gowri Sankar, P. Kadgapathi, R. Suthakaran and B. Satyanarayana

Two simple, sensitive and accurate spectrophotometric methods have been developed for the determination of bisoprolol fumarate in pure and pharmaceutical formulations. The first method is based on the formation of pink colored chromogen condensation product of bisoprolol fumarate with 2, 6-dichloroquinone-4-chloroimide (Gibb’s reagent) having a λ max at 532 nm. The second method is based on the formation of blue colored complex between bisoprolol fumarate and cobalt thiocyanate (CTC). The colored species formed is the coordination complex of the drug and central metal atom of cobalt thiocyanate, which is extractable into nitrobenzene from aqueous solution, which has absorption maxima at 626 nm. The linearity range of bisoprolol fumarate was found to be 100-500 µg/mL for method-1 and 50 -300 µg/mL for method-2. The developed methods were found to be precise and accurate form the statistical validation of the analytical data. So the proposed methods can be used for the routine analysis of bisoprolol fumarate in tablets.

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