All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Preparation and Evaluation of Micronized Suspensions of Piroxicam for Enhanced Dissolution Rate and Bioavailability

Author(s): K. P. R. Chowdary and B. L. R. Madhavi

 Micronized suspensions of piroxicam were prepared by co-precipitation method employing three hydrophilic polymers namely hydroxy propyl methyl cellulose (HPMC), hydroxy ethyl cellulose (HEC) and polyethylene glycol 6000 (PEG) and were evaluated by in vitro and in vivo methods. The

size of the dispersed drug particles was much reduced in the suspensions prepared by co-precipitation method. Suspensions formulated employing HPMC and PEG exhibited good suspendability and gave higher dissolution rate of piroxicam than those formulated employing piroxicam alone. Good linear
relationship was observed between particle size and dissolution efficiency of the suspensions. The rate and extent of absorption of piroxicam was markedly higher in the case of formulation prepared with HPMC (F3) when compared to F1 (conventional). 2.17 and 2.31 fold increase respectively in Ka and
(AUC)o 2.5 h was observed with F3, when compared to F1.

Share this       
Google scholar citation report
Citations : 4270

International Journal of Chemical Sciences received 4270 citations as per google scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research

Read More