Preparation and Evaluation of Micronized Suspensions of Piroxicam for Enhanced Dissolution Rate and Bioavailability
K. P. R. Chowdary and B. L. R. Madhavi
Micronized suspensions of piroxicam were prepared by co-precipitation method employing three hydrophilic polymers namely hydroxy propyl methyl cellulose (HPMC), hydroxy ethyl cellulose (HEC) and polyethylene glycol 6000 (PEG) and were evaluated by in vitro and in vivo methods. The
size of the dispersed drug particles was much reduced in the suspensions prepared by co-precipitation method. Suspensions formulated employing HPMC and PEG exhibited good suspendability and gave higher dissolution rate of piroxicam than those formulated employing piroxicam alone. Good linear
relationship was observed between particle size and dissolution efficiency of the suspensions. The rate and extent of absorption of piroxicam was markedly higher in the case of formulation prepared with HPMC (F3) when compared to F1 (conventional). 2.17 and 2.31 fold increase respectively in Ka and
(AUC)o 2.5 h was observed with F3, when compared to F1.