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Plasma Level of Homocysteine and Lipid Profile in Patients with Cerebrovascular Accident in Tertiary Health Centre in Ogbomoso Oyo State South-West Nigeria

Author(s): JO Akande, AA Salawu, RO Akande, AA Adeomi, EO Oke, TW Oloyede and RA Kareem

Apart from the traditional risk factors, there are newer risk factors such as high plasma level of Homocysteine, Folate deficiency and Vitamin B12 deficiency, associated with cardiovascular disease. Plasma Homocysteine level has been link to the level of LDL-C and functionality of HDL-C. This study is therefore designed to correlate plasma level of Homocysteine with Lipid profile in patient newly diagnosed of cerebrovascular accident. Seventy-Two newly diagnosed stroke patients were consecutively recruited into the study. Seventy-Two apparently healthy, age and sex matched volunteers were recruited from the community as controls. The data obtained were analyzed using SPSS version 20. Level of significance for the study was set at p<0.05. High plasma level of Homocysteine (12.72 ± 5.10 μmol/L), Total-Cholesterol (4.58 ± 1.40 mmol/L) and LDL (3.34 ± 1.41 mmol/L) were obtained from the study population when compared with Homocysteine (7.60 ± 1.80 μmol/L), Total-Cholesterol (3.93 ± 0.91) and LDL (2.23 ± 0.80 mmol/L) obtained from the controls and the difference was highly significant (p<0.01). The difference in the mean plasma level of HDL was statistically significant among study population (0.74 ± 0.32 mmol/L) when compared with Control (1.26 ± 0.38 mmol/L) p<0.001. Homocysteine had weak positive correlations with T-Cholesterol (r=0.172), LDL (r=0.213), Body Fat (r=178) and negative correlation with HDL (r=-0.178) but statistically significant p<0.05. We concluded that elevated plasma level of Homocysteine has significant correlat ion with abnormal lipid profile which is one of the major risk factors for cerebrovascular accident.

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