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Novel Analogues of 1, 5-Benzothiazepine: Synthesis, Characterization and Antimicrobial Evaluation

Author(s): Shrikrishna D. Tupare, Venkat V. Bhadke and Rajendra P. Pawar

The chemistry and pharmacology of thiazoles and thiazolochromenones are of great interest to medicinal chemists nowadays, because they are known to possess a wide range of pharmacological properties. A series of novel 6-(3-((2 Z, 4E)-2-phenylbenzo[b][1,4]thiazepin-4-yl)pyridazin-3(2H)-one were prepared by the reaction of 6-(3-((E)-3-phenylacryloyl) phenyl amino)pyridazin-3(2H)-one with 2-aminobenzenethiol. All compounds were tested for their antimicrobial activity against bacteria and fungi. It is interesting to note that the in heterocyclic compounds containing substituent’s at the 4th position of benzodiazepines system displayed notable antibacterial activity, almost equal to penicillin.

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