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New Spectrophotometric Method for the Estimation of Pantoprazole in Bulk and Pharmaceutical Formulation

Author(s): N. V. Pimpodkar, R. S. Nalawade , B. S. Kuchekar, N. S. Mahajan and R. L. Jadhav

A simple, sensitive, rapid and accurate colorimetric method has been developed for the estimation of pantoprazole in bulk and pharmaceutical dosage forms. This method is based on oxidative coupling reaction of pantoprazole with 3-methyl-2-benzathiazoline hydrazone (MBTH) in presence of ferric ammonium sulphate producing orange red colored chromogen, which exhibits absorption maximum at 504 nm. It obeyed Beer’s law in concentration range of 10-90 μg/mL. The results obtained with the proposed method are in good agreement with labeled amounts, when marketed pharmaceutical preparations are analyzed. Results obtained are statistically validated and found to be reproducible.

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Citations : 4270

International Journal of Chemical Sciences received 4270 citations as per google scholar report

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  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research

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