Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerNatural products-inspired discovery and development of novel anti-microbial, anti-inflammatory and antiplatelet agents| Abstract

Abstract

Natural products-inspired discovery and development of novel anti-microbial, anti-inflammatory and antiplatelet agents

Author(s): Virinder S Parmar

 We have extensively worked on several plant species and isolated a large number of novel compounds belonging to different classes (alkaloids, polyphenols, steroids, amides, terpenoids, etc.). Several of these compounds have shown interesting biological activities, remarkable of them has been our extensive work on polyphenol acetates leading to the discovery of a fundamental biochemical pathway involving acetyl CoA-independent enzymatic protein acetylation. Our seminal investigations have highlighted the unique biochemical and pharmacological action of polyphenol acetates. These act as the substrates for the well-known protein calreticulin and transfer acetyl groups to certain receptor enzymes, such as cytochrome P-450 linked mixed function oxidases (MFO), NADPH cytochrome c reductase, Nitric Oxide Synthase (NOS), protein kinase c (PKC) and glutathione S-transferase (GST) resulting in modulation of their catalytic activities. The purified enzyme from buffalo liver in the presence of 7,8-diacetoxy-4 methylcoumarin (DAMC) and several other polyphenol acetates was found to significantly enhance the NOS activity in human platelets and caused significant vasorelaxation. These polyphenol acetates and several natural products were also found to lower PKC levels and suppress the ICAM-1 and VCAM-1 expression, and were found to be good anti-inflammatory & anti-asthmatic agents. Further, acetyl polyphenols and several other classes of natural products were also found to be excellent inhibitors of chemical and radiation induced clastogenecity, and antifungal agents against various deadly fungal infections viz. botulism and aspergillosis. 

 


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Citations : 748

Acta Chimica and Pharmaceutica Indica received 748 citations as per Google Scholar report

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