Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerNanogel For Breast Cancer Treatment| Abstract

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Abstract

Nanogel For Breast Cancer Treatment

Author(s): Masood F

Breast cancer is the most common malignancy in women globally and is a main reason of mortality, thus requiring more therapeutic advancements. The epirubcin (EPI) is an anthracycline. However, the dose-related cardiotoxicity, neurotoxicity and myelosuppression are main problem associated with the use of available formulation of EPI. The poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV) is considered as an ideal drug carrier due to its non-toxic, biodegradable and biocompatible nature. The blank and EPI loaded PHBV nanoparticles decorated with folic acid and polyethylene glycol were by prepared by nanoprecipitation method. Temperature sensitive hydrogel was prepared by addition of β-glycerophosphate disodium salt (β-GP) solution to chitosan (CS) solution. The CS/GP hydrogel demonstrated a rapid sol-to-gel transition at 37°C. The addition of folate grafted blank and drug loaded nanoparticles did not alter the gelation time of the resulting nanogels. The drug loading efficiency of EPI/FA-PEG-PHBV/CS nanogel was found to be 45.23%. About 60% of total encapsulated drug was released at pH 4 from EPI/FA-PEG-PHBV/CS nanogel during in-vitro release study. Blank FA-PEG-PHBV/CS nanogel did not affect the % viability of MCF7 breast cancer cell line, thus demonstrating their non-toxicity and biocompatibility. The EPI/FA-PEG-PHBV/CS nanogel significantly inhibited the viability and proliferation of cancer cells in comparison to equivalent amount of free drug.


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