44 7460 854 031

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Microwave Assisted Synthesis and Antidepressant Activity of Some 1, 3, 5- Triphenyl- 2-Pyrazolines

Author(s): P. O. Patil, D. P. Belsare, S. B. Kosalge and R. A. Fursule

A series of 1,3,5-triphenyl-2-pyrazoline derivatives were synthesized through microwave assisted condensation of 1,3-diphenyl-2-propene-1-one (chalcones) with phenylhydrazine using dry acetic acid as cyclizing agent and evaluated for antidepressant activity. The chemical structures of the compounds were confirmed by means of their IR, GC-MS and 1H NMR spectroscopic data. The antidepressant activity of these compounds were screened by porsolt behavioral despair test using imipramine as a reference drug. All synthesized 2-pyrazoline derivatives were found to possess significant antidepressant activity. It has been observed that 1,5-diphenyl-3- (4-methoxyphenyl)-2- pyrazoline showed maximum antidepressant activity, comparable with imipramine. A methoxy substituent on the phenyl ring at position 3 of the pyrazoline ring was found to enhance antidepressant activity. The replacement of the methoxy group by methyl and any other electron-withdrawing group decreases antidepressant activity.


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More