Method Development and Validation for Quantitative Analysis of Tigabine HCl by Ultraviolet Spectrophotometry

Author(s): Shrikant Patil, Syed U. K. Asema, Shahid Mirza, Ahmed Zaheer and Maqdoom Farooqui

A simple and sensitive UV spectrophotometric method for the determination of tiagabine HCl in bulk has been developed. Beer’s law is obeyed in the concentration range of 10 – 50 1g / mL of Tiagabine HCl. Spectroscopic determination was carried out at an absorption maximum of 257 nm for tiagabine HCl using double distilled water as a solvent. In UV spectroscopic method the linearity over concentration range of tiagabine HCl was 10 to 50 1g / mL with correlation coefficient 0.99845. The mean assay and recovery percentage was found to be 101.73% and 100.61%, respectively. The results of the analysis for the three methods have been validated statistically and by recovery studies. The results obtained with the proposed methods are in given limit by United States Pharmacopia.

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