Investigation and In Vitro Cytotoxic Activity of Randia Dumetorum Lamk. Bark

Author(s): J. S. Jangwan, Rita Patrizia Aquino, Teresa Mencherini and Raghubir Singh

β-Sitosterol, lupeol and daucosterol have been isolated from ethanolic extract of Randia dumetorum bark. β-Sitosterol, Lupeol and Daucosterol have been isolated for the first time from the Randia dumetorum. β Sitosterol and Daucosterol were identified by complete interpretation of 1H NMR and 13C NMR spectra using 2D NMR (HSQC, HMBC, DQF-COSY) experiments and Lupeol by direct comparison with authentic sample. The ethanolic extract is subjected to cytotoxic activity against A549 cell (adenocarcinomic human alveolar basal epithelial cells), BE (2) C (Neuroblastonoma Cell Line), Hela, MDA-MB-231 (breast cancer cell line), SK MEL-2 (Human Skin Melanoma Cell) and U87MG cell (Human Neuronale Gliblostoma astrozytom Cell Line) which showed most effective cytotoxic activity at 400 μg/mL concentration on MDA-MB-231 (Breast Cancer Cell Line).

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