All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Influence of N-methyl piperidine on Antibacterial Activity of 2-(thioalkyl)-1Hmethylbenzimidazole Derivatives

Author(s): Coulibaly Souleymane, Coulibali Siomenan, Ablo Evrard, Coulibaly Bakary, Camara Tchambaga Etienne and Adjou Ane

Antibiotic resistance becomes a public health issue nowadays. The overcoming and settlement of this ongoing crisis could be to find novel, potent, and selective antimicrobial agents. For that we synthesized 2-(thioalkyl)-1H-methylbenzimidazole derivatives (3a-g) by S-alkylation, and added piperidine via Mannich reaction to yield 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl) benzimidazole derivatives (4a-g). The antimicrobial profiles of both derivatives were first estimated by their inhibition diameters and determined with Minimal Inhibitory Concentrations (MICs) against a small set of bacteria clinical strains of Escherichia coli, Klebsiella pneumoniae (Gram-negative bacteria), Staphylococcus aureus and Pseudomonas aeruginosa (Gram-positive bacteria). The panel of synthesized compounds (3a-g) and (4a-g) were characterized by NMR 1H, 13C spectroscopy, and high-resolution mass spectrometry (HRMS). The results revealed that compounds 3a and 3b, were both bactericidal on P. aeruginosa and E. coli with a great MIC value of 1µg/mL. Then the addition of piperidine show promising inhibition diameter but did not implement the bactericidal activity in terms of MIC on P. aeruginosa.


Share this       

Select your language of interest to view the total content in your interested language

Table of Contents

Google Scholar citation report
Citations : 230

ChemXpress received 230 citations as per Google Scholar report

Indexed In

  • CASS
  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Cosmos IF
  • Directory of Research Journal Indexing (DRJI)
  • Secret Search Engine Labs
  • Scholar Article Impact Factor (SAJI))

Read More

Recommended Conferences

Flyer
Global Tech Summit