Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerInfluence of N-methyl piperidine on Antibacterial Activity of 2-(thioalkyl)-1Hmethylbenzimidazole Derivatives| Abstract
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Abstract

Influence of N-methyl piperidine on Antibacterial Activity of 2-(thioalkyl)-1Hmethylbenzimidazole Derivatives

Author(s): Coulibaly Souleymane, Coulibali Siomenan, Ablo Evrard, Coulibaly Bakary, Camara Tchambaga Etienne and Adjou Ane

Antibiotic resistance becomes a public health issue nowadays. The overcoming and settlement of this ongoing crisis could be to find novel, potent, and selective antimicrobial agents. For that we synthesized 2-(thioalkyl)-1H-methylbenzimidazole derivatives (3a-g) by S-alkylation, and added piperidine via Mannich reaction to yield 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl) benzimidazole derivatives (4a-g). The antimicrobial profiles of both derivatives were first estimated by their inhibition diameters and determined with Minimal Inhibitory Concentrations (MICs) against a small set of bacteria clinical strains of Escherichia coli, Klebsiella pneumoniae (Gram-negative bacteria), Staphylococcus aureus and Pseudomonas aeruginosa (Gram-positive bacteria). The panel of synthesized compounds (3a-g) and (4a-g) were characterized by NMR 1H, 13C spectroscopy, and high-resolution mass spectrometry (HRMS). The results revealed that compounds 3a and 3b, were both bactericidal on P. aeruginosa and E. coli with a great MIC value of 1µg/mL. Then the addition of piperidine show promising inhibition diameter but did not implement the bactericidal activity in terms of MIC on P. aeruginosa.


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