Abstract

Impact of P2 (Hb A1C) and P3 window in normal HPLC

Author(s): S.Pandey, R.Saxena, R.M.Mishra, U.K.Chauhan, M.Sharma, Sw.Pandey

High performance liquid chromatography is an important tool for detection of Hb variants and its role has been established in prenatal diagnosis and carrier screening. We had evaluated fifteen suspected cases with normal HPLC. Patients were presenting significant clinical symptom. This study revealed few Hb variant may clinically associated with normal HPLC and produce significant pathophsiology when co inherited. So care should be taken by clinician and never ignore the unidentified peaks in HPLC.