Hydroxy-apatites-catalysed Biginelli reaction under solvent- free conditions

Author(s): BirgitMaaten, MichelGruselle, KadriKriis, Tõnis Kanger, Kaia Tõnsuaadu

TheBiginelli reaction catalysed by nonmodified hydroxy-apatites (HAp) and Zn(II)-, Pd(II)- and Cu(II) modified HAp in different conditions is described. HAp and Cu-HAp appear to be the best catalysts even under solvent free conditions. This efficient solvent-free environmentallybenignmethod for three-component coupling of a 1,3-dicarbonyl compound, urea and benzaldehyde (Biginelli reac-catation) catalysed byhydroxy-apatiteswas developed.The catalystwas easilyrecovered and repeatedlyusedwithout significant loss of activity.

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