Formulation and Evaluation of Fast Disintegrating Tablets of Domperidone By Using Plantago Ovata Mucilage

Author(s): S. M. Shahidulla, Mohib Khan and K. N. Jayaveera

In the presence study, fast disintegrating tablets of domperidone were prepared to enhance patient compliance by direct compression method. In the presence study, to prepare fast disintegrating tablets of the drug using, plantago ovata mucilage and crospovidone were used as superdisintegrants (2.5 to 10 % w/w) along with microcrystalline cellulose (20 to 60 % w/w) and directly compressible mannitol (pearlitol SD 200) to enhance mouth feel. The prepared tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time (approximately 10 s), the two formulations were tested for the in vitro drug release, short term stability (at 400/75% RH for 3 months) and drug excipient interaction (IR spectroscopy). Among the two promising formulations, the formulations prepared by using 10% w/w of plantago ovata mucilage and 60% w/w of MCC as emerged as the overall best formulation (t50% 2.75 min.) compared to conventional commercial tablets formulation (t50% 10.20 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro dispersion time (p < 0.05).

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